Tamoxifen Undergoes Optimization Essay -- Medical Drug

Tamoxifen Undergoes OptimizationAbstractComputer programs like GaussView and Gaussian 03W be or so of the advanced toolsthat can be used by scientists to figure of speech and optimise new designed medicate. Using the exact sametools as scientists today, I am going to take a known drug, Tamoxifen, and make out few line of latitudessimilar to its organize. Before I can create some analogs in GaussView, I am going to study andexamine the structure of Tamoxifen to understand the chemistry that involves in this structure.For example, the bonds between molecules and the interactions between the drug and estrogenreceptor complex site. After I design an analog of Tamoxifen, I will then use the Gaussian 03Wprogram to optimize the analog. As for the last step in determining if an analog is a goodcandidate for a new designed drug, I am going to use a special computer program calledOpenEye softw be product to help me make that prediction.IntroductionBreast Cancer is the most prevalent t ype of cancer known among wo workforce in the US. It isthe second-leading cause of cancer-related deaths. More than 180,000 women argon mentiond with boob cancer each year. In 2006, out of all of these women, 40,000 died. Although detractor cancermainly mends women, data shows that men can also be affected as well each year more than1,000 men are diagnosed with breast cancer 3. This information shows that cancer can affectanyone regardless of an individuals gender, ethnicity, etc. It is important that everyone knowsabout breast cancer and helps friends or family members with breast cancer to find way todiagnose it. In nowadays, scientists are learning more about cancer and are exploring new waysto prevent, detect, diagnose, and treat this deadly disease 1.... ...c., 1997.3. Corey, E. J., Barbara Czako, and Laszlo Kurti. Molecules and medicine. New island of Jersey JohnWiley &Sons, Inc., 2007.4. Jordan, V., ed. Long-Term Tamoxifen interference for Breast Cancer. Wisconsin TheUni versity of Wisconsin Press, 1994.5. Oxford University Press. Figure 18.44 Tamoxifen. Online preference Centre. 29 Jul. 2008.tamoxifen.jpg.6. Wikipedia. Tamoxifen. Wikipedia. 29 Jul. 2008..7. Wiseman, Helen. Tamoxifen-Molecular Basis of Use in Cancer Treatment and Prevention.England John Wiley &Sons Ltd, 1994.8. Nolte, RT. Crystal structure of Estrogen Related Reecptor-3 (ERR-gamma) ligand bindingdomaind with tamoxifen analog GSK5182. Protein Data Bank. 29 Jul. 2008..